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Unless you have strong connections, B2B sales cycles are longer than B2C. You need to take that fact into consideration when you raise funds. Also, B2B is more service friendly than product. So, depending on what you're planning to 'sell', you may want to consider your strengths before doing so. Even if you plan to sell a physical product in both segments, B2B will turn into product + service business vs, B2C may stay as product.