I have worked with many entrepreneurs as part of the senior management team. Where I have seen the biggest issue is a founder/CEO who lacks the self awareness to recognize their strengths and weaknesses. E.g., just because you are a smart scientist or engineer does not make you a smart business person. Someone who is aware of that is usually open to coaching or bringing on team members who fill the gaps in the founder's strengths. Someone who believes that because they had a success or they are a smart scientist means they are smart at everything will resist or ignore guidance and not seek team members to fill the gaps.
For example, I am both an entrepreneurial business exec and an attorney. I was serving as part time COO of a small startup that got into a dispute with a contract engineering support firm over the quality of work done. Basically it came down to negotiating a contract dispute. You would think the CEO/engineer just might listen to his COO/lawyer about how to best negotiate a legal dispute, but no, he totally ignored my advice and agreed to pay the vendor substantiallymore than necessary, to the serious detriment of his company.
We all have strengths and areas where we are less capable.. The smart entrepreneur recognizes how to seek coaching or bring on support to ensure those areas where he/she is not as effective get handled in the best manner possible.