What kind of printing?
For canvass, wrap, and photo-paper printing, CircleGraphics does a pretty good job and has a lot of technical integration available to make this fairly easy.
For more paper, print, paper image, or product printing, PFL.com does really well and I've found their support and onboarding to be excellent. I'm sure they both overlap services quite a bit, so depending on what you need, it never hurts to talk to both.
If you are doing book publishing or similar, I'm not sure if either of the above supports what you'd need (but they might).
I've used both to limited degrees and have found them both easy to work with, but glancing at each of their websites, they don't seem to have a lot of their integration information easily available, so you may need to call and chat more directly.
(Obligatory Disclaimer: these are my personal recommendations and do not necessarily represent the opinion of any past or current client or employer.)