The question is too generic to answer. Impact in what sense, exactly? In particular, for better or worse?
For example, some claim that having a President Trump increases the chances of a nuclear war. Suppose it does. Would that have an impact on entrepreneurs? I suppose it would, but how exactly? Would it make entrepreneurship more difficult because all your prospective clients are dead and money is meaningless, or would rebuilding the world from ashes provide an enormous opportunity for innovation (plus, all your competitors would be dead)? Who can say.